GliaSite Radiation Therapy

The GliaSite Radiation Therapy System is a method for treating newly diagnosed, metastatic and recurrent brain tumors. Radiation is delivered from within the cavity created when the tumor is surgically removed. Being a site-specific, internal radiation treatment, this form of brachytherapy delivers a high dose directly to the surrounding tissue of the original cancer site, thereby radiating the area of greatest recurrence. The therapy minimizes radiation exposure to healthy brain tissue and is less disruptive for the patient. Treatment time is shortened to less than a week, as compared to six weeks with an external beam. Side effects are minimal, making for a better quality of life for the patient.

When the tumor is removed, a balloon catheter is implanted and filled with saline and a contrast solution to determine the appropriate volume. For additional safety, the balloon catheter is actually a double balloon. The patient is discharged after a short postoperative intensive care stay, then returns several days later for an MRI to assess how the catheter is conforming to the cavity.

The radiation oncologist plans treatment by determining the radiation dose and treatment depth. He or she then deflates the balloon and refills it to the same volume with a combination of liquid radioactive iodine and saline. This solution emits radiation that directly targets the area while minimizing the exposure to healthy tissue. The balloon delivers radiation for three to seven days; the length of time is dependent upon the radiation oncologist's treatment plan. Patients remain hospitalized during the course of treatment and may have visitors. After the treatment time is complete, the radioactive solution is withdrawn and the catheter is removed.